1．雅施达

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【中文释文】：

(培哚普利)4mg

〔包装和成分〕

10片盒装和30片盒装，每刻痕药片含4mg培哚普利特丁胺盐。

〔药理特性〕

此药是一种血管紧张素转换酶抑制剂。

〔适应证〕

高血压与充血性心力衰竭。

〔禁忌证〕

在下述情况禁止使用本药：

·有培哚普利高敏史

·怀孕，哺乳期

·儿童

若有任何疑问，请向医生查询。

〔副作用〕

与其他药物一样，本品对部分人可能有副作用，如：

·胃肠道不适，眩晕，痉挛，局部皮疹

·干咳偶会出现

若上述情况持续，请通知你的医生。

〔警告〕

接受血液透析的病人可能有过敏反应。

病人应向医生查询。若您必须进行血液透析，则应预先告知你的医生。

〔预防措施〕

若有下述情况，请预先告知你的医生：

·肾功能衰竭

·明显低血压

·若需接受手术治疗，请告知麻醉师你正服用此药，或正接受严格的低盐饮食。

·若有任何疑问，请向你的医生或药剂师查询。

为防止药物相互作用，若你正服用其他药物，特别是利尿剂，请告知你的医生或药剂师。

药物不应放在孩童可触及的地方。

〔剂量和用法〕

在任何情形下，应严格按医嘱服药。

〔高血压〕

建议剂量为每天早晨口服一片4mg药片，服药一个月后，若有需要，可增至2片／d，一次服用。

〔充血性心力衰竭〕

治疗必须在严密的医疗监护下开始。初始剂量为每天早晨口服半片，当已证实血压满意后可增至1片／d。

老年病人应以每天早晨服半片开始治疗。若有需要，可于一个月后增至1片／d。

肾衰竭病人的剂量应根据肾功能不全的程度调整，并应常规作定期的血钾和肌酐测定。

〔服药过量〕

无论是意外或有意服药过量，必须立即通知医生，并提供所有有关资料。预料的症状和体征都与低血压有关。除洗胃外，应立即建立静脉通道作等渗盐水输液。

培哚普利是可透析的(70ml／min)。

〔贮存期〕

若超过包装盒上印明的期限，切勿使用。

〔贮存条件〕

30℃以下。

〔生产厂家〕

法国施维雅药厂

【外文释文】：

Perindopril

Presentation and composition

Boxes of 10 and 30 scored tablets dosed at 4 mg of perindopril salified with tert butylamine．

Properties

This drug is an angiotensin converting enzyme inhibitor．

Indications

This drug is recommended in the treatment of hypertension and of congestive heart failure．

Contraindications

This drug must not be used in the following circumstances：

·history of hypersensitivity to perindopirl．

·pregnancy，breast-feeding．

·in children．

If in any doubt，ask your physician．

Side effects

As with all active products，this drug may cause indesirable effects in certain people：

·gastrointestinal disorders，dizziness，cramps，localized rashes．

·a nonproductive cough may sometimes occur．

If these problems persist，inform your physician．

Warning

Risk of allergic reaction in patients undergoing hemodialysis．

Warn your doctor(if you must be hemodialysed)．

Precautions

Wam your attending physician in case of：

·renal failure．

·marked hypotension．

·if you are about to undergo surgery，warn the anaesthetist that you are taking this drug or following a strictly“salt-free”diet．

·If in any doubt，do not hesitate to ask your doctor or pharmacist．

To prevent any interactions between several drugs，systematically inform your doctor or pharmacist if you are taking any other medications and in particular a diuretic．

Keep out of the reach of children．

Dosage and administration

In any case strictly comply with your physician’s prescription．

Systemic hypertension

The recommended dosage is 1 tablet daily by oral route in the morning．This may be increased to 2 tablets daily in a single dose，if necessary，after one month of treatment．

Congestive heart failure

The treatment should be started under close medical supervision．

Initial dose of half a tablet daily orally in the morming which may be increased to 1 tablet daily(once blood pressure acceptability has been demonstrated)．

·In the elderly patient，treatment should be started with half a tablet daily in the moming and this may be increased to 1 tablet daily，if necessary after one month of treatment．

·In case of renal failure，the dosage of perindopril must be adjusted according to the degree of renal insufficiency．In these patients，normal medical practice involves periodic determination of serum potassium and creatinine．

Overdosage

In case of accidental or deliberate overdosage a doctor must be consulted immediately and given the maximum information．

The expected signs and symptoms are related to hypotension．

Apart from gastric lavage，a venous line should rapidly be inserted for infusion with isotonic saline．

Perindopril is dialysable(70ml／min)．

Shelf-life

Do not use after the expiry date clearly indicated on the packaging．

Storage conditions

Below 30℃．

Manufacturer

les Laboratoires Servier，France